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Research Article

Safety and Efficacy of Single Dose versus Multiple Doses of AmBisome® for Treatment of Visceral Leishmaniasis in Eastern Africa: A Randomised Trial

  • Eltahir A. G. Khalil,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Teklu Weldegebreal,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP State, Arba Minch, Ethiopia

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  • Brima M. Younis,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Raymond Omollo,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi) Africa Regional Office, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Ahmed M. Musa,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Workagegnehu Hailu,

    Affiliation: University of Gondar, College of Medicine & Health Sciences, Gondar, Ethiopia

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  • Abuzaid A. Abuzaid,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Thomas P. C. Dorlo,

    Affiliations: Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Zewdu Hurissa,

    Affiliation: University of Gondar, College of Medicine & Health Sciences, Gondar, Ethiopia

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  • Sisay Yifru,

    Affiliation: University of Gondar, College of Medicine & Health Sciences, Gondar, Ethiopia

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  • William Haleke,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP State, Arba Minch, Ethiopia

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  • Peter G. Smith,

    Affiliation: MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Sally Ellis,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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  • Manica Balasegaram,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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  • Ahmed M. EL-Hassan,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Gerard J. Schoone,

    Affiliation: Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands

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  • Monique Wasunna,

    Affiliations: Drugs for Neglected Diseases initiative (DNDi) Africa Regional Office, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Robert Kimutai,

    Affiliations: Drugs for Neglected Diseases initiative (DNDi) Africa Regional Office, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Tansy Edwards,

    Affiliation: MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Asrat Hailu mail

    hailu_a2004@yahoo.com, a_hailu@hotmail.com

    Affiliation: School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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  • Published: January 16, 2014
  • DOI: 10.1371/journal.pntd.0002613

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