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Research Article

Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis

  • Manuel Modolell,

    Affiliation: Department of Cellular Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Beak-San Choi,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Robert O. Ryan,

    Affiliation: Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, Oakland, California, United States of America

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  • Maggie Hancock,

    Affiliation: Imperial College Healthcare NHS Trust, Chelsea and Westminster Hospital, London, United Kingdom

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  • Richard G. Titus,

    Affiliation: Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America

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  • Tamrat Abebe,

    Affiliation: Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia

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  • Asrat Hailu,

    Affiliation: Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia

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  • Ingrid Müller,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Matthew E. Rogers,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Charles R. M. Bangham,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Markus Munder,

    Affiliation: Department of Hematology, Oncology, and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

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  • Pascale Kropf mail

    p.kropf@mperial.ac.uk

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Published: July 14, 2009
  • DOI: 10.1371/journal.pntd.0000480

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