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Research Article

Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

  • Asrat Hailu,

    Affiliation: Addis Ababa University, Addis Ababa, Ethiopia

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  • Ahmed Musa,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Monique Wasunna mail,

    africa@dndi.org

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Manica Balasegaram,

    Affiliations: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands, Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Sisay Yifru,

    Affiliation: Gondar University, Gondar, Ethiopia

    X
  • Getahun Mengistu,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Zewdu Hurissa,

    Affiliation: Gondar University, Gondar, Ethiopia

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  • Workagegnehu Hailu,

    Affiliation: Gondar University, Gondar, Ethiopia

    X
  • Teklu Weldegebreal,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP state, Arba Minch, Ethiopia

    X
  • Samson Tesfaye,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP state, Arba Minch, Ethiopia

    X
  • Eyasu Makonnen,

    Affiliation: Addis Ababa University, Addis Ababa, Ethiopia

    X
  • Eltahir Khalil,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Osama Ahmed,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Ahmed Fadlalla,

    Affiliation: Faculty of Medicine, Gedaref University, Gedaref, Sudan

    X
  • Ahmed El-Hassan,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Muzamil Raheem,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

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  • Marius Mueller,

    Affiliation: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands

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  • Yousif Koummuki,

    Affiliation: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands

    X
  • Juma Rashid,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Jane Mbui,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Geoffrey Mucee,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Simon Njoroge,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Veronica Manduku,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Alice Musibi,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Geoffrey Mutuma,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Fredrick Kirui,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Hudson Lodenyo,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Dedan Mutea,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • George Kirigi,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Tansy Edwards,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Peter Smith,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Lawrence Muthami,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Catherine Royce,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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  • Sally Ellis,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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  • Moses Alobo,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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  • Raymond Omollo,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Josephine Kesusu,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Rhoda Owiti,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • John Kinuthia,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • for the Leishmaniasis East Africa Platform (LEAP) group
  • Published: October 26, 2010
  • DOI: 10.1371/journal.pntd.0000709

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Linked Articles

Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding Study

Ahmed M. Musa, Brima Younis, Ahmed Fadlalla, Catherine Royce, Manica Balasegaram, Monique Wasunna, Asrat Hailu, Tansy Edwards, Raymond Omollo, Mahmoud Mudawi, Gilbert Kokwaro, ...
Research Article | published 26 Oct 2010 | PLOS Neglected Tropical Diseases
doi:10.1371/journal.pntd.0000855