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Research Article

Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

  • Sven N. Hobbie,

    Affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

    Current address: Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore

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  • Marcel Kaiser,

    Affiliations: Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Sebastian Schmidt,

    Affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

    Current address: Roche Diagnostics, Rotkreuz, Switzerland

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  • Dmitri Shcherbakov,

    Affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

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  • Tanja Janusic,

    Affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

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  • Reto Brun,

    Affiliations: Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Erik C. Böttger mail

    boettger@imm.uzh.ch

    Affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

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  • Published: May 24, 2011
  • DOI: 10.1371/journal.pntd.0001161

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