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Research Article

Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4+CD8+ T Cells in Severe Forms of Human Disease

  • Alexandre Morrot mail,

    morrot@micro.ufrj.br

    Affiliations: Department of Immunology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Eugênia Terra-Granado,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Ana Rosa Pérez,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Suse Dayse Silva-Barbosa,

    Affiliations: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Department of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil

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  • Novica M. Milićević,

    Affiliation: Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Beograd, Serbia

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  • Désio Aurélio Farias-de-Oliveira,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Luiz Ricardo Berbert,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Juliana De Meis,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Christina Maeda Takiya,

    Affiliation: Biomedical Science Institute, Cell Pathology Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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  • Juan Beloscar,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Xiaoping Wang,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Vivian Kont,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Pärt Peterson,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Oscar Bottasso,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Wilson Savino

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Published: August 16, 2011
  • DOI: 10.1371/journal.pntd.0001268

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