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Research Article

Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity

  • Peifang Sun mail,

    peifang.sun@med.navy.mil

    Affiliations: Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America

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  • Josefina García,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Guillermo Comach,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Maryanne T. Vahey,

    Affiliation: Division of Retrovirology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Zhining Wang,

    Affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America

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  • Brett M. Forshey,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Amy C. Morrison,

    Affiliations: US Naval Medical Research Unit No. 6, Lima, Peru, Department of Entomology, University of California at Davis, Davis, California, United States of America

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  • Gloria Sierra,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Isabel Bazan,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Claudio Rocha,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Stalin Vilcarromero,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Patrick J. Blair,

    Affiliation: US Naval Medical Research Unit No. 2 – Pacific, American Embassy Singapore, Singapore

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  • Thomas W. Scott,

    Affiliation: Department of Entomology, University of California at Davis, Davis, California, United States of America

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  • Daria E. Camacho,

    Affiliation: Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales (LARDIDEV), Instituto de Investigaciones Biomédicas de la Universidad de Carabobo (BIOMED-UC), Maracay, Venezuela

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  • Christian F. Ockenhouse,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Eric S. Halsey,

    Affiliation: US Naval Medical Research Unit No. 6, Lima, Peru

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  • Tadeusz J. Kochel

    Affiliation: Naval Medical Research Center, Silver Spring, Maryland, United States of America

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  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002298

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