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Research Article

A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease

  • Suganya Selvarajah,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Nicole R. Sexton,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

    Current address: Vanderbilt University, Nashville, Tennessee, United States of America

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  • Kristen M. Kahle,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Rachel H. Fong,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Kimberly-Anne Mattia,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Joy Gardner,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Kai Lu,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Nathan M. Liss,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Beatriz Salvador,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • David F. Tucker,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Trevor Barnes,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Manu Mabila,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Xiangdong Zhou,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Giada Rossini,

    Affiliation: DIMES, Microbiology, University of Bologna, Bologna, Italy

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  • Joseph B. Rucker,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • David Avram Sanders,

    Affiliation: Purdue University, West Lafayette, Indiana, United States of America

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  • Andreas Suhrbier,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Vittorio Sambri,

    Affiliation: DIMES, Microbiology, University of Bologna, Bologna, Italy

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  • Alain Michault,

    Affiliation: Centre Hospitalier Universitaire, Groupe Hospitalier Sud-Réunion, La Reunion, France

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  • Marcus O. Muench,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Benjamin J. Doranz,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Graham Simmons mail

    gsimmons@bloodsystems.org

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: September 12, 2013
  • DOI: 10.1371/journal.pntd.0002423

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