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Research Article

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

  • Gregory J. Crowther,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

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  • Michael L. Booker,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

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  • Min He,

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Ting Li,

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

    X
  • Sylvine Raverdy,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Jacopo F. Novelli,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Panqing He,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Natalie R. G. Dale,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Amy M. Fife,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

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  • Robert H. Barker Jr,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

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  • Martin L. Kramer,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

    X
  • Wesley C. Van Voorhis,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

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  • Clotilde K. S. Carlow,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Ming-Wei Wang mail

    wangmw@mail.shcnc.ac.cn

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

    X
  • Published: January 09, 2014
  • DOI: 10.1371/journal.pntd.0002628

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