A review of efficacy and effectiveness studies of vaccination among individuals with chronic parasitic infections suggests that chronic trematode, nematode, and protozoan infections can result in decreased vaccine efficacy. Additional data suggest that antiparasite therapy can improve the effectiveness of several human vaccines, and thus better control of chronic NTDs may prove imperative.
The authors identify multiple genes active in tissues from sections of female S. japonicum, and say that their approach has allowed them to formulate the basis of a "gene atlas" for schistosome parasites that defines the expression repertoire of specific tissues.
Researchers identify factors that put pregnant women in Entebbe at particular risk for worm infections, malaria, HIV, and, where possible, rarer infections including syphilis. Their findings also highlight which groups are most at risk of each infection, which may help in targeting interventions to prevent, treat, or mitigate the impact of infections in pregnancy.
Researchers conducted an observational study of households in two scabies-endemic Aboriginal communities in northern Australia in which a community-based skin health program was operating, and report that the effectiveness of the program was compromised by poor treatment uptake by household contacts of infested children and high ongoing disease transmission.
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