Addressing the social stigma resulting from many of the NTDs could be as important for achieving Millennium Development Goals and sustainable poverty reduction as mass drug administration and the development of new vaccines and other control tools.
River blindness research has been hampered by a lack of good animal models. This review highlights the development of two animal model systems—Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle—that have allowed recent significant advances and hold promise for control of the disease in humans.
Researchers analyze the relationship between the A,F,E components of the SAFE strategy and the prevalence of trachoma following three years of interventions in four districts in southern Sudan.
Image Credit: Aslam Bashir, Aga Khan University
Mary Warrell and colleagues show that a simple, four-site intradermal regimen following a rabid animal bite is at least as effective as the intramuscular method favored internationally, and they recommend that the four-site regimen be used wherever the cost of vaccine is prohibitive.
In this prevalence survey of a slum community in Brazil, researchers use GIS and modeling approaches to identify specific deficiencies in the sanitation infrastructure that serve as sources for Leptospira transmission, but they also find that low socioeconomic status independently contributes to the risk of infection.
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